Free NFL Betting Odds & Picks for the Seattle Seahawks vs. Arizona Cardinals week 1 matchup. The Seahawks are a 3 point road favorite. The over/under is 41. The Arizona Cardinals are 5-1 in their last six games, Seattle is 4-1-1 against the spread in their last six road games. Seattle will go with the mobile Russell Wilson at QB over newly acquired Matt Flynn. Braylon Edwards and Marshawn Lynch will be the X-factors.