Free NFL Betting Odds & Picks for the San Francisco 49ers vs. Seattle Seahawks week 16 matchup. The Seahawks are a 1.5 point underdog. The over/under is 38. The 49ers are 2-6 SU in their last 8 in Seattle. The Seahawks are 5-1 SU in their last 6, and 6-3 SU, 7-2 ATS in their last 9 at home. No Sidney Rice and no Mike Williams means that Golden Tate, Doug Baldwin and Ben Obomanu will be in charge.